Skinperfect Primer

CIR Safety Assessment of Cyclomethicone and Dimethicone as Used in Cosmetics: The CIR Expert Panel concluded dimethicone is safe as used in cosmetic formulations. It functions as a skin protectant and emollient, forming a breathable barrier on skin that reduces transepidermal water loss.

CTPA Ingredient Library — Dimethicone: CTPA lists dimethicone as a safe skin-conditioning agent and emollient widely used in cosmetics to improve skin feel and texture. It is considered safe for all skin types and is non-sensitising.

CIR Safety Assessment of Cyclomethicone (D4, D5, D6) as Used in Cosmetics: The CIR Expert Panel found cyclopentasiloxane (D5) safe as used in cosmetics. It functions as a lightweight volatile silicone that improves formula texture and spreadability without leaving residue. The Panel found no significant dermal sensitisation or irritation at cosmetic concentrations.

CTPA Ingredient Library — Cyclopentasiloxane: CTPA notes that cyclopentasiloxane (D5) is subject to restrictions under EU Cosmetics Regulation: it is limited to concentrations below 0.1% in rinse-off cosmetics due to environmental persistence concerns. It remains permitted in leave-on cosmetics and is considered safe for skin application.

FDA GRAS Database — Glycerin: Glycerin (glycerol) is affirmed as Generally Recognized As Safe (GRAS) by the FDA. As a cosmetic ingredient, it is one of the most widely used and well-tolerated humectants, drawing moisture from the environment to the outer layers of the skin.

Niacinamide (Vitamin B3) — FDA Cosmetic Ingredient Review: Niacinamide is considered safe for use in cosmetics. It is a well-established skin-conditioning agent with evidence supporting its role in improving skin texture, tone, and barrier function.

CTPA Ingredient Library — Niacinamide: CTPA lists niacinamide as a safe and effective skin-conditioning agent widely used across cosmetic formulations, with a strong safety profile across concentrations typically used in cosmetics (2–10%).

FDA Briefing on Hyaluronic Acid in Topical Formulations: Sodium hyaluronate is generally recognized as safe (GRAS) as a cosmetic ingredient. It functions as an effective humectant and skin-conditioning agent suitable for all skin types.

FDA OTC Skin Protectant Active Ingredient — Allantoin: The FDA recognises allantoin as a safe and effective OTC skin protectant active ingredient at concentrations of 0.5–2.0%. It soothes and protects irritated skin and helps relieve minor skin irritation from chapping, chafing, and wind.

CTPA Ingredient Library — Allantoin: CTPA lists allantoin as a safe, soothing skin-conditioning agent with a long history of safe use as a skin protectant. It is well tolerated by sensitive and reactive skin types.

CIR Safety Assessment of Panthenol as Used in Cosmetics: The CIR Expert Panel found panthenol (provitamin B5) safe as used in cosmetic formulations. It functions as a humectant and skin-conditioning agent, improving skin hydration and supporting barrier function, with no significant irritation or sensitisation concerns.

CTPA Ingredient Library — Panthenol: CTPA lists panthenol as a safe humectant and skin-conditioning agent. As provitamin B5, it supports healthy skin cell metabolism. It is well tolerated and considered safe for sensitive skin.

FDA — Phenoxyethanol in Cosmetics: FDA has reviewed phenoxyethanol as a cosmetic preservative and considers it safe at concentrations up to 1.0% in cosmetic products. FDA advises caution in products used around the mouth of infants.

CTPA Ingredient Library — Phenoxyethanol: CTPA confirms phenoxyethanol is a permitted cosmetic preservative under EU Cosmetics Regulation at a maximum concentration of 1.0%, and is considered safe for use in both rinse-off and leave-on products.

CTPA Ingredient Library — Chlorphenesin: Chlorphenesin is a permitted cosmetic preservative under EU Cosmetics Regulation (max 0.3% in rinse-off, max 0.2% in leave-on products). CTPA considers it safe when used within these limits.